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Kinase-KCC2 coupling: Cl(−) rheostasis, disease susceptibility, therapeutic target

The intracellular concentration of Cl(−) ([Cl(−)](i)) in neurons is a highly regulated variable that is established and modulated by the finely tuned activity of the KCC2 cotransporter. Despite the importance of KCC2 for neurophysiology and its role in multiple neuropsychiatric diseases, our knowled...

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Bibliographic Details
Published in:J Neurophysiol
Main Authors: Kahle, Kristopher T., Delpire, Eric
Format: Artigo
Language:Inglês
Published: American Physiological Society 2015
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4760510/
https://ncbi.nlm.nih.gov/pubmed/26510764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/jn.00865.2015
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