Current view on the functional regulation of the neuronal K(+)-Cl(−) cotransporter KCC2

In the mammalian central nervous system (CNS), the inhibitory strength of chloride (Cl(−))-permeable GABA(A) and glycine receptors (GABA(A)R and GlyR) depends on the intracellular Cl(−) concentration ([Cl(−)](i)). Lowering [Cl(−)](i) enhances inhibition, whereas raising [Cl(−)](i) facilitates neuron...

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Bibliographic Details
Main Authors: Medina, Igor, Friedel, Perrine, Rivera, Claudio, Kahle, Kristopher T., Kourdougli, Nazim, Uvarov, Pavel, Pellegrino, Christophe
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2014
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3915100/
https://ncbi.nlm.nih.gov/pubmed/24567703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fncel.2014.00027
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