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Generation of TCRs of higher affinity by antigen-driven differentiation of progenitor T cells in vitro
Many promising targets for T cell-based cancer immunotherapies are self-antigens. During thymic selection, T cells bearing TCRs with high affinity for self-antigen are eliminated. The affinity of the remaining low avidity TCRs can be improved to increase their anti-tumor efficacy, but conventional s...
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| Published in: | Nat Biotechnol |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2017
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5722674/ https://ncbi.nlm.nih.gov/pubmed/29106410 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.4004 |
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