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Comparison of T cell activities mediated by human TCRs and CARs that use the same recognition domains

Adoptive T cell therapies have achieved significant clinical responses, especially in hematopoietic cancers. Two types of receptor systems have been used to redirect the activity of T cells, normal heterodimeric T-cell receptors (TCRs) or synthetic chimeric antigen receptors (CARs). TCRs recognize p...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Harris, Daniel T., Hager, Marlies V., Smith, Sheena N., Cai, Qi, Stone, Jennifer D., Kruger, Philipp, Lever, Melissa, Dushek, Omer, Schmitt, Thomas M., Greenberg, Philip D., Kranz, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5780198/
https://ncbi.nlm.nih.gov/pubmed/29288199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700236
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