Aminoglycoside resistance profile and structural architecture of the aminoglycoside acetyltransferase AAC(6')-Im

Aminoglycoside 6’-acetyltransferase-Im (AAC(6’)-Im) is the closest monofunctional homolog of the AAC(6’)-Ie acetyltransferase of the bifunctional enzyme AAC(6’)-Ie/APH(2”)-Ia. The AAC(6’)-Im acetyltransferase confers 4- to 64-fold higher MICs to 4,6-disubstituted aminoglycosides and the 4,5-disubsti...

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Publicado en:Microb Cell
Autores principales: Smith, Clyde A., Bhattacharya, Monolekha, Toth, Marta, Stewart, Nichole K., Vakulenko, Sergei B.
Formato: Artigo
Lenguaje:Inglês
Publicado: Shared Science Publishers OG 2017
Materias:
Microbiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5722643/
https://ncbi.nlm.nih.gov/pubmed/29234669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15698/mic2017.12.602
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