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AMP-activated protein kinase: a target for drugs both ancient and modern
The AMP-activated protein kinase (AMPK) is a sensor of cellular energy status. It is activated, by a mechanism requiring the tumor suppressor LKB1, by metabolic stresses that increase cellular ADP:ATP and/or AMP:ATP ratios. Once activated, it switches on catabolic pathways that generate ATP, while s...
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| Veröffentlicht in: | Chem Biol |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5722193/ https://ncbi.nlm.nih.gov/pubmed/23102217 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2012.08.019 |
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