Myc Cooperates with Ras by Programming Inflammation and Immune Suppression

The two oncogenes KRas and Myc cooperate to drive tumorigenesis, but the mechanism underlying this remains unclear. In a mouse lung model of KRas(G12D)-driven adenomas, we find that co-activation of Myc drives the immediate transition to highly proliferative and invasive adenocarcinomas marked by hi...

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Détails bibliographiques
Publié dans:Cell
Auteurs principaux: Kortlever, Roderik M., Sodir, Nicole M., Wilson, Catherine H., Burkhart, Deborah L., Pellegrinet, Luca, Brown Swigart, Lamorna, Littlewood, Trevor D., Evan, Gerard I.
Format: Artigo
Langue:Inglês
Publié: Cell Press 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5720393/
https://ncbi.nlm.nih.gov/pubmed/29195074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.11.013
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