Human Brain-Derived Aβ Oligomers Bind to Synapses and Disrupt Synaptic Activity in a Manner That Requires APP

Compelling genetic evidence links the amyloid precursor protein (APP) to Alzheimer's disease (AD) and several theories have been advanced to explain the relationship. A leading hypothesis proposes that a small amphipathic fragment of APP, the amyloid β-protein (Aβ), self-associates to form solu...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Wang, Zemin, Jackson, Rosemary J., Hong, Wei, Taylor, Walter M., Corbett, Grant T., Moreno, Arturo, Liu, Wen, Li, Shaomin, Frosch, Matthew P., Slutsky, Inna, Young-Pearse, Tracy L., Spires-Jones, Tara L., Walsh, Dominic M.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5719975/
https://ncbi.nlm.nih.gov/pubmed/29101243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2009-17.2017
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