Citrullination of NF-kB p65 enhances its nuclear localization and TLR-induced expression of IL-1β and TNFα

Citrullination converts peptidyl-arginine to peptidyl-citrulline and is mediated by the enzymes peptidyl arginine deiminases (PADs), including PAD1–4 and PAD6. The physiological role of citrullination in immune cells is poorly understood. Here we report that suppression of PAD activity attenuates TL...

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Udgivet i:Sci Immunol
Main Authors: Sun, Bo, Dwivedi, Nishant, Bechtel, Tyler J., Paulsen, Janet L., Muth, Aaron, Bawadekar, Mandar, Li, Gang, Thompson, Paul R., Shelef, Miriam A., Schiffer, Celia A., Weerapana, Eranthie, Ho, I-Cheng
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5718838/
https://ncbi.nlm.nih.gov/pubmed/28783661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aal3062
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