PAD1 promotes epithelial-mesenchymal transition and metastasis in triple-negative breast cancer cells by regulating MEK1-ERK1/2-MMP2 signaling

Peptidylargininedeiminase 1 (PAD1) catalyzes protein for citrullination, and this activity has been linked to the epidermal cornification. However, a role for PAD1 in tumorigenesis, including breast cancers has not been previously explored. Here we first showed that PAD1 is overexpressed in human tr...

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Detalhes bibliográficos
Publicado no:Cancer Lett
Main Authors: Qin, Hao, Liu, Xiaoqiu, Li, Fujun, Miao, Lixia, Li, Tingting, Xu, Boqun, An, Xiaofei, Muth, Aaron, Thompson, Paul R, Coonrod, Scott A, Zhang, Xuesen
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5718050/
https://ncbi.nlm.nih.gov/pubmed/28844713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2017.08.019
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