Lack of chemopreventive effects of P2X7R inhibitors against pancreatic cancer

Pancreatic cancer (PC) is an almost uniformly lethal disease with inflammation playing an important role in its progression. Sustained stimulation of purinergic receptor P2X7 drives induction of NLRP inflammasome activation. To understand the role of P2X7 receptor and inflammasome, we performed tran...

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Udgivet i:Oncotarget
Main Authors: Mohammed, Altaf, Janakiram, Naveena B., Madka, Venkateshwar, Pathuri, Gopal, Li, Qian, Ritchie, Rebekah, Biddick, Laura, Kutche, Hannah, Zhang, Yuting, Singh, Anil, Gali, Hariprasad, Lightfoot, Stan, Steele, Vernon E., Suen, Chen S., Rao, Chinthalapally V.
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5716694/
https://ncbi.nlm.nih.gov/pubmed/29228654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22085
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