SP-A2 contributes to miRNA-mediated sex differences in response to oxidative stress: pro-inflammatory, anti-apoptotic, and anti-oxidant pathways are involved

BACKGROUND: Human innate host defense molecules, surfactant protein A1 (SP-A1), and SP-A2 differentially affect the function and proteome of the alveolar macrophage (AM). We hypothesized that SP-A genes differentially regulate the AM miRNome. METHODS: Humanized transgenic mice expressing SP-A1 and S...

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Detalhes bibliográficos
Publicado no:Biol Sex Differ
Main Authors: Noutsios, George T., Thorenoor, Nithyananda, Zhang, Xuesheng, Phelps, David S., Umstead, Todd M., Durrani, Faryal, Floros, Joanna
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5716385/
https://ncbi.nlm.nih.gov/pubmed/29202868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13293-017-0158-2
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