Survival of Surfactant Protein-A1 and SP-A2 Transgenic Mice After Klebsiella pneumoniae Infection, Exhibits Sex-, Gene-, and Variant Specific Differences; Treatment With Surfactant Protein Improves Survival

Surfactant protein A (SP-A) is involved in lung innate host defense and surfactant-related functions. The human SFTPA1 and SFTPA2 genes encode SP-A1 and SP-2 proteins, and each gene has been identified with numerous genetic variants. SP-A1 and SP-A2 differentially enhance bacterial phagocytosis. Sex...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Thorenoor, Nithyananda, Umstead, Todd M., Zhang, Xuesheng, Phelps, David S., Floros, Joanna
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6232836/
https://ncbi.nlm.nih.gov/pubmed/30459763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.02404
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