Differential effects of innate immune variants of surfactant protein-A1 (SFTPA1) and SP-A2 (SFTPA2) in airway function after Klebsiella pneumoniae infection and sex differences

BACKGROUND: Surfactant Protein-A (SP-A) is a major protein component of surfactant and plays a role in surfactant-related functions and innate immunity. Human SP-A consists of two functional genes, SFTPA1 and SFTPA2, encoding SP-A1 and SP-A2 proteins, respectively and each is identified with numerou...

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Detalhes bibliográficos
Publicado no:Respir Res
Main Authors: Thorenoor, Nithyananda, Zhang, Xuesheng, Umstead, Todd M., Scott Halstead, E., Phelps, David S., Floros, Joanna
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
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Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5797374/
https://ncbi.nlm.nih.gov/pubmed/29394894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-018-0723-1
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