Generation of RORγt(+) antigen-specific T regulatory 17 (Tr17) cells from Foxp3(+) precursors in autoimmunity

Th17 cells are potent mediators in autoimmune diseases and RORγt is required for their development. Recent studies have shown that RORγt(+) Treg cells in the gut regulate intestinal inflammation by inhibiting effector T cell function. In the current study, we report that RORγt(+) Treg cells were als...

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Udgivet i:Cell Rep
Main Authors: Kim, Byung-Seok, Lu, Huiping, Ichiyama, Kenji, Chen, Xiang, Zhang, Yi-Bing, Mistry, Nipun A, Tanaka, Kentaro, Lee, Young-hee, Nurieva, Roza, Zhang, Li, Yang, Xuexian, Chung, Yeonseok, Jin, Wei, Chang, Seon Hee, Dong, Chen
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5716359/
https://ncbi.nlm.nih.gov/pubmed/28978473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.09.021
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