Rac3 regulates breast cancer invasion and metastasis by controlling adhesion and matrix degradation

The initial step of metastasis is the local invasion of tumor cells into the surrounding tissue. Invadopodia are actin-based protrusions that mediate the matrix degradation necessary for invasion and metastasis of tumor cells. We demonstrate that Rac3 GTPase is critical for integrating the adhesion...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Donnelly, Sara K., Cabrera, Ramon, Mao, Serena P.H., Christin, John R., Wu, Bin, Guo, Wenjun, Bravo-Cordero, Jose Javier, Condeelis, John S., Segall, Jeffrey E., Hodgson, Louis
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5716284/
https://ncbi.nlm.nih.gov/pubmed/29061650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201704048
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