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Talin regulates moesin–NHE-1 recruitment to invadopodia and promotes mammary tumor metastasis

Invadopodia are actin-rich protrusions that degrade the extracellular matrix and are required for stromal invasion, intravasation, and metastasis. The role of the focal adhesion protein talin in regulating these structures is not known. Here, we demonstrate that talin is required for invadopodial ma...

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Detalhes bibliográficos
Main Authors: Beaty, Brian T., Wang, Yarong, Bravo-Cordero, Jose Javier, Sharma, Ved P., Miskolci, Veronika, Hodgson, Louis, Condeelis, John
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4050723/
https://ncbi.nlm.nih.gov/pubmed/24891603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201312046
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