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Talin regulates moesin–NHE-1 recruitment to invadopodia and promotes mammary tumor metastasis

Invadopodia are actin-rich protrusions that degrade the extracellular matrix and are required for stromal invasion, intravasation, and metastasis. The role of the focal adhesion protein talin in regulating these structures is not known. Here, we demonstrate that talin is required for invadopodial ma...

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Библиографические подробности
Главные авторы: Beaty, Brian T., Wang, Yarong, Bravo-Cordero, Jose Javier, Sharma, Ved P., Miskolci, Veronika, Hodgson, Louis, Condeelis, John
Формат: Artigo
Язык:Inglês
Опубликовано: The Rockefeller University Press 2014
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4050723/
https://ncbi.nlm.nih.gov/pubmed/24891603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201312046
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