Talin regulates moesin–NHE-1 recruitment to invadopodia and promotes mammary tumor metastasis

Invadopodia are actin-rich protrusions that degrade the extracellular matrix and are required for stromal invasion, intravasation, and metastasis. The role of the focal adhesion protein talin in regulating these structures is not known. Here, we demonstrate that talin is required for invadopodial ma...

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Main Authors: Beaty, Brian T., Wang, Yarong, Bravo-Cordero, Jose Javier, Sharma, Ved P., Miskolci, Veronika, Hodgson, Louis, Condeelis, John
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2014
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4050723/
https://ncbi.nlm.nih.gov/pubmed/24891603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201312046
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