An efficient method for generation of bi-allelic null mutant mouse embryonic stem cells and its application for investigating epigenetic modifiers

Mouse embryonic stem (ES) cells are a popular model system to study biological processes, though uncovering recessive phenotypes requires inactivating both alleles. Building upon resources from the International Knockout Mouse Consortium (IKMC), we developed a targeting vector for second allele inac...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Fisher, Cynthia L., Marks, Hendrik, Cho, Lily Ting-yin, Andrews, Robert, Wormald, Sam, Carroll, Thomas, Iyer, Vivek, Tate, Peri, Rosen, Barry, Stunnenberg, Hendrik G., Fisher, Amanda G., Skarnes, William C.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Methods Online
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5716182/
https://ncbi.nlm.nih.gov/pubmed/28981838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx811
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