Intramuscular Delivery of Replication-defective Herpes Simplex Virus Gives Antigen Expression in Muscle Syncytia and Improved Protection Against Pathogenic HSV-2 Strains

Herpes simplex virus 2 (HSV-2) is the leading cause of genital herpes and increases the risk of HIV infection, but there is no effective vaccine. A replication-defective HSV-2 mutant virus, dl5-29, is effective in animal models and has been in a phase I trial. Previous studies have shown that dl5-29...

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Vydáno v:Virology
Hlavní autoři: Diaz, Fernando, Gregory, Sean, Nakashima, Hiroshi, Viapiano, Mariano S., Knipe, David M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5715658/
https://ncbi.nlm.nih.gov/pubmed/29069622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2017.10.011
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