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Intramuscular Delivery of Replication-defective Herpes Simplex Virus Gives Antigen Expression in Muscle Syncytia and Improved Protection Against Pathogenic HSV-2 Strains
Herpes simplex virus 2 (HSV-2) is the leading cause of genital herpes and increases the risk of HIV infection, but there is no effective vaccine. A replication-defective HSV-2 mutant virus, dl5-29, is effective in animal models and has been in a phase I trial. Previous studies have shown that dl5-29...
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| Udgivet i: | Virology |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5715658/ https://ncbi.nlm.nih.gov/pubmed/29069622 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2017.10.011 |
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