Gα(12) facilitates shortening in human airway smooth muscle by modulating phosphoinositide 3‐kinase‐mediated activation in a RhoA‐dependent manner

BACKGROUND AND PURPOSE: PI3K‐dependent activation of Rho kinase (ROCK) is necessary for agonist‐induced human airway smooth muscle cell (HASMC) contraction, and inhibition of PI3K promotes bronchodilation of human small airways. The mechanisms driving agonist‐mediated PI3K/ROCK axis activation, howe...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Yoo, Edwin J, Cao, Gaoyuan, Koziol‐White, Cynthia J, Ojiaku, Christie A, Sunder, Krishna, Jude, Joseph A, Michael, James V, Lam, Hong, Pushkarsky, Ivan, Damoiseaux, Robert, Di Carlo, Dino, Ahn, Kwangmi, An, Steven S, Penn, Raymond B, Panettieri, Reynold A
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5715591/
https://ncbi.nlm.nih.gov/pubmed/28921504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14040
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