Inhibition of PI3K promotes dilation of human small airways in a rho kinase‐dependent manner

BACKGROUND AND PURPOSE: Asthma manifests as a heterogeneous syndrome characterized by airway obstruction, inflammation and hyperresponsiveness (AHR). Although the molecular mechanisms remain unclear, activation of specific PI3K isoforms mediate inflammation and AHR. We aimed to determine whether inh...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Koziol‐White, Cynthia J, Yoo, Edwin J, Cao, Gaoyuan, Zhang, Jie, Papanikolaou, Eleni, Pushkarsky, Ivan, Andrews, Adam, Himes, Blanca E, Damoiseaux, Robert D, Liggett, Stephen B, Di Carlo, Dino, Kurten, Richard C, Panettieri, Reynold A
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4995285/
https://ncbi.nlm.nih.gov/pubmed/27352269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13542
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