Inhibition of PI3K promotes dilation of human small airways in a rho kinase‐dependent manner

BACKGROUND AND PURPOSE: Asthma manifests as a heterogeneous syndrome characterized by airway obstruction, inflammation and hyperresponsiveness (AHR). Although the molecular mechanisms remain unclear, activation of specific PI3K isoforms mediate inflammation and AHR. We aimed to determine whether inh...

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書目詳細資料
發表在:Br J Pharmacol
Main Authors: Koziol‐White, Cynthia J, Yoo, Edwin J, Cao, Gaoyuan, Zhang, Jie, Papanikolaou, Eleni, Pushkarsky, Ivan, Andrews, Adam, Himes, Blanca E, Damoiseaux, Robert D, Liggett, Stephen B, Di Carlo, Dino, Kurten, Richard C, Panettieri, Reynold A
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2016
主題:
Research Papers
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4995285/
https://ncbi.nlm.nih.gov/pubmed/27352269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13542
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