Genome-wide prediction of DNase I hypersensitivity using gene expression

We evaluate the feasibility of using a biological sample’s transcriptome to predict its genome-wide regulatory element activities measured by DNase I hypersensitivity (DH). We develop BIRD, Big Data Regression for predicting DH, to handle this high-dimensional problem. Applying BIRD to the Encyclope...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Zhou, Weiqiang, Sherwood, Ben, Ji, Zhicheng, Xue, Yingchao, Du, Fang, Bai, Jiawei, Ying, Mingyao, Ji, Hongkai
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5715040/
https://ncbi.nlm.nih.gov/pubmed/29051481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01188-x
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