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Hsp90 inhibitor sensitizes TRAIL-mediated apoptosis via chop-dependent DR5 upregulation in colon cancer cells

Heat shock protein 90 (Hsp90), a molecular chaperone, is involved in a variety of physiological and pathological processes. Targeting Hsp90 by small molecules has been developed as an attractive strategy of anticancer therapy. In this study, we investigated the mechanism of Hsp90 inhibitor suppresse...

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Vydáno v:Am J Transl Res
Hlavní autoři: Yao, Zhicheng, Chen, Ang, Li, Xin, Zhu, Zhiyong, Jiang, Xin
Médium: Artigo
Jazyk:Inglês
Vydáno: e-Century Publishing Corporation 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5714778/
https://ncbi.nlm.nih.gov/pubmed/29218092
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