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MDL-12330A potentiates TRAIL-induced apoptosis in gastric cancer cells through CHOP-mediated DR5 upregulation
MDL-12330A is a widely used adenylyl cyclase (AC) inhibitor that blocks AC/cAMP signaling. In this study, we demonstrated a novel antitumor activity of this drug in gastric carcinoma (GC) cell lines. In these GC cells, MDL-12330A reduced cell viability and induced cell death in a concentration-depen...
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| Publicado no: | Korean J Physiol Pharmacol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Korean Physiological Society and The Korean Society of Pharmacology
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5507778/ https://ncbi.nlm.nih.gov/pubmed/28706453 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4196/kjpp.2017.21.4.397 |
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