Amiodarone sensitizes human glioma cells but not astrocytes to TRAIL-induced apoptosis via CHOP-mediated DR5 upregulation

Amiodarone is a widely used anti-arrhythmic drug that inhibits diverse ion channels, including the Na(+)/Ca(2+) exchanger (NCX), L-type Ca(2+) channels, and Na(+) channels. Here, we report that subtoxic doses of amiodarone and tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) synergist...

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Detalhes bibliográficos
Main Authors: Kim, In Young, Kang, You Jung, Yoon, Mi Jin, Kim, Eun Hee, Kim, Seung U, Kwon, Taeg Kyu, Kim, In Ah, Choi, Kyeong Sook
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064603/
https://ncbi.nlm.nih.gov/pubmed/21292685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noq195
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