Paxilline enhances TRAIL-mediated apoptosis of glioma cells via modulation of c-FLIP, survivin and DR5

Tumor necrosis factor-related apoptosis-induced ligand (TRAIL) induces apoptosis selectively in cancer cells while sparing normal cells. However, many cancer cells are resistant to TRAIL-induced cell death. Here, we report that paxilline, an indole alkaloid from Penicillium paxilli, can sensitize va...

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Detalhes bibliográficos
Main Authors: Kang, You Jung, Kim, In Young, Kim, Eun Hee, Yoon, Mi Jin, Kim, Seung U, Kwon, Taeg Kyu, Choi, Kyeong Sook
Formato: Artigo
Idioma:Inglês
Publicado em: Korean Society for Biochemistry and Molecular Biology 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3041935/
https://ncbi.nlm.nih.gov/pubmed/21150246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3858/emm.2011.43.1.003
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