Chloroquine enhances TRAIL-mediated apoptosis through up-regulation of DR5 by stabilization of mRNA and protein in cancer cells

Chloroquine (CQ), an anti-malarial drug, has immune-modulating activity and lysosomotropic activity. In this study, we investigated CQ sensitizes TRAIL-mediated apoptosis in human renal cancer Caki cells. Combination of CQ and TRAIL significantly induces apoptosis in human renal cancer Caki cells an...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Park, Eun Jung, Min, Kyoung-jin, Choi, Kyeong Sook, Kubatka, Peter, Kruzliak, Peter, Kim, Dong Eun, Kwon, Taeg Kyu
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4786792/
https://ncbi.nlm.nih.gov/pubmed/26964637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22921
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