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MDL-12330A potentiates TRAIL-induced apoptosis in gastric cancer cells through CHOP-mediated DR5 upregulation

MDL-12330A is a widely used adenylyl cyclase (AC) inhibitor that blocks AC/cAMP signaling. In this study, we demonstrated a novel antitumor activity of this drug in gastric carcinoma (GC) cell lines. In these GC cells, MDL-12330A reduced cell viability and induced cell death in a concentration-depen...

詳細記述

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書誌詳細
出版年:Korean J Physiol Pharmacol
主要な著者: Lim, Sung-Chul, Han, Song Iy
フォーマット: Artigo
言語:Inglês
出版事項: The Korean Physiological Society and The Korean Society of Pharmacology 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5507778/
https://ncbi.nlm.nih.gov/pubmed/28706453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4196/kjpp.2017.21.4.397
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