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CRISPR/Cas9-based genome editing for simultaneous interference with gene expression and protein stability

Interference with genes is the foundation of reverse genetics and is key to manipulation of living cells for biomedical and biotechnological applications. However, classical genetic knockout and transcriptional knockdown technologies have different drawbacks and offer no control over existing protei...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Martínez, Virginia, Lauritsen, Ida, Hobel, Tonja, Li, Songyuan, Nielsen, Alex Toftgaard, Nørholm, Morten H. H.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5714205/
https://ncbi.nlm.nih.gov/pubmed/28981713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx797
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