FANCI and FANCD2 have common as well as independent functions during the cellular replication stress response

Fanconi anemia (FA) is an inherited cancer predisposition syndrome characterized by cellular hypersensitivity to DNA interstrand crosslinks (ICLs). To repair these lesions, the FA proteins act in a linear hierarchy: following ICL detection on chromatin, the FA core complex monoubiquitinates and recr...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Thompson, Elizabeth L., Yeo, Jung E., Lee, Eun-A, Kan, Yinan, Raghunandan, Maya, Wiek, Constanze, Hanenberg, Helmut, Schärer, Orlando D., Hendrickson, Eric A., Sobeck, Alexandra
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Molecular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5714191/
https://ncbi.nlm.nih.gov/pubmed/29059323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx847
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