A trishistidine pseudopeptide with ability to remove both Cu(i) and Cu(ii) from the amyloid-β peptide and to stop the associated ROS formation

The pseudopeptide L, derived from a nitrilotriacetic acid scaffold and functionalized with three histidine moieties, is reminiscent of the amino acid side chains encountered in the Alzheimer’s peptide (Aβ). Its synthesis and coordination properties for Cu(i) and Cu(ii) are described. L efficiently c...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Chemistry
Hlavní autoři: Conte-Daban, A., Boff, B., Candido Matias, A., Aparicio, C. N. Montes, Gateau, C., Lebrun, C., Cerchiaro, G., Kieffer, I., Sayen, S., Guillon, E., Delangle, P., Hureau, C.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5714062/
https://ncbi.nlm.nih.gov/pubmed/28846165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201703429
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky