A High-Throughput UHPLC-MS/MS Method for the Quantification of Five Aged Butyrylcholinesterase Biomarkers from Human Exposure to Organophosphorus Nerve Agents

Organophosphorus nerve agents (OPNAs) are toxic compounds that are classified as prohibited Schedule 1 chemical weapons. In the body, OPNAs bind to butyrylcholinesterase (BChE) to form nerve agent adducts (OPNA-BChE). OPNA-BChE adducts can provide a reliable, long-term protein biomarker for assessin...

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Udgivet i:Biomed Chromatogr
Main Authors: Graham, Leigh Ann, Johnson, Darryl, Carter, Melissa D., Stout, Emily G., Erol, Huseyin A., Isenberg, Samantha L., Mathews, Thomas P., Thomas, Jerry D., Johnson, Rudolph C.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5713885/
https://ncbi.nlm.nih.gov/pubmed/27572107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bmc.3830
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