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Direct Quantitation of Methyl Phosphonate Adducts to Human Serum Butyrylcholinesterase by Immunomagnetic-UHPLC-MS/MS

Hydrolysis of G- and V-series organophosphorus nerve agents containing a phosphorus-methyl bond yields a methylphosphonic acid (MeP) product when adducted to human butyrylcholinesterase (BChE). The MeP adduct is considered a sign of “aging” and results in loss of the o-alkyl identifier specific to e...

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Dettagli Bibliografici
Pubblicato in:Anal Chem
Autori principali: Carter, Melissa D., Crow, Brian S., Pantazides, Brooke G., Watson, Caroline M., Thomas, Jerry D., Blake, Thomas A., Johnson, Rudolph C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5713886/
https://ncbi.nlm.nih.gov/pubmed/24205842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac4029714
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