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Direct Quantitation of Methyl Phosphonate Adducts to Human Serum Butyrylcholinesterase by Immunomagnetic-UHPLC-MS/MS
Hydrolysis of G- and V-series organophosphorus nerve agents containing a phosphorus-methyl bond yields a methylphosphonic acid (MeP) product when adducted to human butyrylcholinesterase (BChE). The MeP adduct is considered a sign of “aging” and results in loss of the o-alkyl identifier specific to e...
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| Publicado no: | Anal Chem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5713886/ https://ncbi.nlm.nih.gov/pubmed/24205842 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac4029714 |
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