Mechanisms of acquired resistance to BRAF V600E inhibition in colon cancers converge on RAF dimerization and are sensitive to its inhibition

BRAF V600E colorectal cancers (CRC) are insensitive to RAF inhibitor monotherapy due to feedback reactivation of receptor tyrosine kinase signaling. Combined RAF and EGFR inhibition exerts a therapeutic effect, but resistance invariably develops through undefined mechanisms. In this study, we determ...

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Vydáno v:Cancer Res
Hlavní autoři: Yaeger, Rona, Yao, Zhan, Hyman, David M., Hechtman, Jaclyn F., Vakiani, Efsevia, Zhao, HuiYong, Su, Wenjing, Wang, Lu, Joelson, Andrew, Cercek, Andrea, Baselga, Jose, de Stanchina, Elisa, Saltz, Leonard, Berger, Michael F., Solit, David B., Rosen, Neal
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5712250/
https://ncbi.nlm.nih.gov/pubmed/28951457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-0768
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