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Mechanisms of acquired resistance to BRAF V600E inhibition in colon cancers converge on RAF dimerization and are sensitive to its inhibition

BRAF V600E colorectal cancers (CRC) are insensitive to RAF inhibitor monotherapy due to feedback reactivation of receptor tyrosine kinase signaling. Combined RAF and EGFR inhibition exerts a therapeutic effect, but resistance invariably develops through undefined mechanisms. In this study, we determ...

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التفاصيل البيبلوغرافية
الحاوية / القاعدة:	Cancer Res
المؤلفون الرئيسيون:	Yaeger, Rona, Yao, Zhan, Hyman, David M., Hechtman, Jaclyn F., Vakiani, Efsevia, Zhao, HuiYong, Su, Wenjing, Wang, Lu, Joelson, Andrew, Cercek, Andrea, Baselga, Jose, de Stanchina, Elisa, Saltz, Leonard, Berger, Michael F., Solit, David B., Rosen, Neal
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	2017
الموضوعات:	Article
الوصول للمادة أونلاين:	https://ncbi.nlm.nih.gov/pmc/articles/PMC5712250/ https://ncbi.nlm.nih.gov/pubmed/28951457 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-0768
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Mechanisms of acquired resistance to BRAF V600E inhibition in colon cancers converge on RAF dimerization and are sensitive to its inhibition

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