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Reduced mutation rate in exons due to differential mismatch repair

While recent studies have revealed higher than anticipated heterogeneity of mutation rate across genomic regions, mutations in exons and introns are assumed to be generated at the same rate. Here we find fewer somatic mutations in exons than expected based on their sequence content, and demonstrate...

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Detalles Bibliográficos
Publicado en:Nat Genet
Main Authors: Frigola, Joan, Sabarinathan, Radhakrishnan, Mularoni, Loris, Muiños, Ferran, Gonzalez-Perez, Abel, López-Bigas, Núria
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5712219/
https://ncbi.nlm.nih.gov/pubmed/29106418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3991
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