Composition and regulation of the cellular repertoire of SCF ubiquitin ligases

SCF (Skp1-Cullin-F-box) ubiquitin ligases comprise several dozen modular enzymes that have diverse roles in biological regulation. SCF enzymes share a common catalytic core containing Cul1•Rbx1, which is directed towards different substrates by a variable substrate receptor (SR) module comprising on...

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Udgivet i:Cell
Main Authors: Reitsma, Justin M., Liu, Xing, Reichermeier, Kurt M., Moradian, Annie, Sweredoski, Michael J., Hess, Sonja, Deshaies, Raymond J.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5711595/
https://ncbi.nlm.nih.gov/pubmed/29103612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.10.016
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