Tumor-associated macrophages promote neuroblastoma via STAT3 phosphorylation and up-regulation of c-MYC

Tumor-associated macrophages (TAMs) are strongly associated with poor survival in neuroblastomas that lack MYCN amplification. To study TAM action in neuroblastomas, we used a novel murine model of spontaneous neuroblastoma lacking MYCN amplification, and observed recruitment and polarization of TAM...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Hadjidaniel, Michael D., Muthugounder, Sakunthala, Hung, Long T., Sheard, Michael A., Shirinbak, Soheila, Chan, Randall Y., Nakata, Rie, Borriello, Lucia, Malvar, Jemily, Kennedy, Rebekah J., Iwakura, Hiroshi, Akamizu, Takashi, Sposto, Richard, Shimada, Hiroyuki, DeClerck, Yves A., Asgharzadeh, Shahab
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5710942/
https://ncbi.nlm.nih.gov/pubmed/29207662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21066
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