The IGF-1R/AKT pathway has opposing effects on Nutlin-3a-induced apoptosis

Nutlin-3a is a small molecule MDM2 antagonist and potent activator of wild-type p53. Nutlin-3a disrupts MDM2 binding to p53, thus increasing p53 levels and allowing p53 to inhibit proliferation or induce cell death. Factors that control sensitivity to Nutlin-3a-induced apoptosis are incompletely und...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Cancer Biol Ther
Hauptverfasser: Davaadelger, Batzaya, Perez, Ricardo E., Zhou, Yalu, Duan, Lei, Gitelis, Steven, Maki, Carl G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2017
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5710671/
https://ncbi.nlm.nih.gov/pubmed/28696156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2017.1345397
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