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The IGF-1R/AKT pathway has opposing effects on Nutlin-3a-induced apoptosis
Nutlin-3a is a small molecule MDM2 antagonist and potent activator of wild-type p53. Nutlin-3a disrupts MDM2 binding to p53, thus increasing p53 levels and allowing p53 to inhibit proliferation or induce cell death. Factors that control sensitivity to Nutlin-3a-induced apoptosis are incompletely und...
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| Publicado no: | Cancer Biol Ther |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5710671/ https://ncbi.nlm.nih.gov/pubmed/28696156 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2017.1345397 |
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