Computational correction of copy-number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells

The CRISPR-Cas9 system has revolutionized gene editing both on single genes and in multiplexed loss-of-function screens, enabling precise genome-scale identification of genes essential to proliferation and survival of cancer cells(1,2). However, previous studies reported that a gene-independent anti...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Nat Genet
Hlavní autoři: Meyers, Robin M., Bryan, Jordan G., McFarland, James M., Weir, Barbara A., Sizemore, Ann E., Xu, Han, Dharia, Neekesh V., Montgomery, Phillip G., Cowley, Glenn S., Pantel, Sasha, Goodale, Amy, Lee, Yenarae, Ali, Levi D., Jiang, Guozhi, Lubonja, Rakela, Harrington, William F., Strickland, Matthew, Wu, Ting, Hawes, Derek C., Zhivich, Victor A., Wyatt, Meghan R., Kalani, Zohra, Chang, Jaime J., Okamoto, Michael, Stegmaier, Kimberly, Golub, Todd R., Boehm, Jesse S., Vazquez, Francisca, Root, David E., Hahn, William C., Tsherniak, Aviad
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5709193/
https://ncbi.nlm.nih.gov/pubmed/29083409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3984
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky