Computational correction of copy-number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells

The CRISPR-Cas9 system has revolutionized gene editing both on single genes and in multiplexed loss-of-function screens, enabling precise genome-scale identification of genes essential to proliferation and survival of cancer cells(1,2). However, previous studies reported that a gene-independent anti...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Nat Genet
Autori principali: Meyers, Robin M., Bryan, Jordan G., McFarland, James M., Weir, Barbara A., Sizemore, Ann E., Xu, Han, Dharia, Neekesh V., Montgomery, Phillip G., Cowley, Glenn S., Pantel, Sasha, Goodale, Amy, Lee, Yenarae, Ali, Levi D., Jiang, Guozhi, Lubonja, Rakela, Harrington, William F., Strickland, Matthew, Wu, Ting, Hawes, Derek C., Zhivich, Victor A., Wyatt, Meghan R., Kalani, Zohra, Chang, Jaime J., Okamoto, Michael, Stegmaier, Kimberly, Golub, Todd R., Boehm, Jesse S., Vazquez, Francisca, Root, David E., Hahn, William C., Tsherniak, Aviad
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5709193/
https://ncbi.nlm.nih.gov/pubmed/29083409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3984
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi