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Effects of genetic variants of human P450 oxidoreductase on catalysis by CYP2D6 in vitro
OBJECTIVES: P450 oxidoreductase (POR) donates electrons to all microsomal cytochrome P450s, including drug-metabolizing and steroidogenic enzymes. Severe POR mutations cause skeletal malformations and disordered steroidogenesis. The POR polymorphism A503V is found on ~28% of human alleles and decrea...
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| Publicado no: | Pharmacogenet Genomics |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5708132/ https://ncbi.nlm.nih.gov/pubmed/20940534 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0b013e32833f4f9b |
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