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Synergistic gene expression during the acute phase response is characterized by transcription factor assisted loading
The cytokines interleukin 1β and 6 (IL-1β, IL-6) mediate the acute phase response (APR). In liver, they regulate the secretion of acute phase proteins. Using RNA-seq in primary hepatocytes, we show that these cytokines regulate transcription in a bifurcated manner, leading to both synergistic and an...
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| Publicado en: | Nat Commun |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5707366/ https://ncbi.nlm.nih.gov/pubmed/29185442 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02055-5 |
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