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A Daple-Akt feed-forward loop enhances noncanonical Wnt signals by compartmentalizing β-catenin

Cellular proliferation is antagonistically regulated by canonical and noncanonical Wnt signals; their dysbalance triggers cancers. We previously showed that a multimodular signal transducer, Daple, enhances PI3-K→Akt signals within the noncanonical Wnt signaling pathway and antagonistically inhibits...

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Publicat a:Mol Biol Cell
Autors principals: Aznar, Nicolas, Sun, Nina, Dunkel, Ying, Ear, Jason, Buschman, Matthew D., Ghosh, Pradipta
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Cell Biology 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5706997/
https://ncbi.nlm.nih.gov/pubmed/29021338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E17-06-0405
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