Expression of PTEN‐long mediated by CRISPR/Cas9 can repress U87 cell proliferation

PTEN is a tumour suppressor that is frequently mutated in a variety of cancers. Hence, PTEN has significant potential as a therapeutic molecule. PTEN‐long is an alternative translation variant, with an additional 173 amino acids added to the N‐terminal of the canonical PTEN when CUG of the mRNA is u...

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Bibliografski detalji
Izdano u:J Cell Mol Med
Glavni autori: Fang, Na, Gu, Tingxuan, Wang, Yahui, Wang, Shuzhen, Wang, Fengling, An, Yang, Wei, Wenqiang, Zhang, Weijuan, Guo, Xiangqian, Nazarali, Adil J, Ji, Shaoping
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2017
Teme:
Original Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5706501/
https://ncbi.nlm.nih.gov/pubmed/28631420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.13236
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