Degradation of PHLPP2 by KCTD17, via a Glucagon-dependent Pathway, Promotes Hepatic Steatosis

BACKGROUND & AIMS: Obesity-induced non-alcoholic fatty liver disease (NAFLD) develops, in part, via excess insulin-stimulated hepatic de novo lipogenesis, which increases, paradoxically, in patients with obesity-induced insulin resistance. Pleckstrin homology domain leucine-rich repeat protein p...

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Udgivet i:Gastroenterology
Main Authors: Kim, KyeongJin, Ryu, Dongryeol, Dongiovanni, Paola, Ozcan, Lale, Nayak, Shruti, Ueberheide, Beatrix, Valenti, Luca, Auwerx, Johan, Pajvani, Utpal B.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5705280/
https://ncbi.nlm.nih.gov/pubmed/28859855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2017.08.039
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