Prospective Blinded Study of BRAFV600E Mutation Detection in Cell-Free DNA of Patients with Systemic Histiocytic Disorders

Patients with Langerhans Cell Histiocytosis (LCH) and Erdheim-Chester Disease (ECD) have a high frequency of BRAFV600E mutations and respond to RAF inhibitors. However, detection of mutations in tissue biopsies is particularly challenging in histiocytoses due to low tumor content and stromal contami...

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Библиографические подробности
Опубликовано в: :Cancer Discov
Главные авторы: Hyman, David M., Diamond, Eli L, Vibat, Cecile Rose T., Hassaine, Latifa, Poole, Jason C., Patel, Minal, Holley, Veronica R., Cabrilo, Goran, Lu, Timothy T., Arcila, Maria E., Chung, Young Rock, Rampal, Raajit, Lacouture, Mario E., Rosen, Neal, Meric-Bernstam, Funda, Baselga, Jose, Kurzrock, Razelle, Erlander, Mark G., Janku, Filip, Abdel-Wahab, Omar
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5705028/
https://ncbi.nlm.nih.gov/pubmed/25324352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-14-0742
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